June had no idea that GPT-5 was coming. The Norwegian student was enjoying a late-night writing session last Thursday when her ChatGPT collaborator started acting strange. “It started forgetting everything, and it wrote really badly,” she says. “It was like a robot.” June, who asked that we use only her first name for privacy reasons, first began using ChatGPT for help with her schoolwork. But she eventually realized that the service—and especially its 4o model, which seemed particularly attuned to users’ emotions—could do much more than solve math problems. It wrote stories with her, helped her navigate her chronic illness, […]

Using artificial intelligence, MIT researchers have come up with a new way to design nanoparticles that can more efficiently deliver RNA vaccines and other types of RNA therapies. After training a machine-learning model to analyze thousands of existing delivery particles, the researchers used it to predict new materials that would work even better. The model also enabled the researchers to identify particles that would work well in different types of cells, and to discover ways to incorporate new types of materials into the particles. “What we did was apply machine-learning tools to help accelerate the identification of optimal ingredient mixtures […]

With help from artificial intelligence, MIT researchers have designed novel antibiotics that can combat two hard-to-treat infections: drug-resistant Neisseria gonorrhoeae and multi-drug-resistant Staphylococcus aureus (MRSA). Using generative AI algorithms, the research team designed more than 36 million possible compounds and computationally screened them for antimicrobial properties. The top candidates they discovered are structurally distinct from any existing antibiotics, and they appear to work by novel mechanisms that disrupt bacterial cell membranes. This approach allowed the researchers to generate and evaluate theoretical compounds that have never been seen before — a strategy that they now hope to apply to identify and design […]